Clinical studies show that folate, vitamin B12, and vitamin B6 are vital in the metabolism of homocysteine. Vitamin B12 and folate are required by the enzyme that converts homocysteine back to methionine. Vitamin B6 is required in each of the two enzymatic reactions that convert homocysteine to cysteine. Betaine, in the form of trimethylglycine, is included in this supplement to promote the absorption of these important nutrients. Homocysteine Factors provides vitamin B6, vitamin B12, folate and betaine, a highly bioavailable combination of nutrients integral to supporting normal homocysteine levels and cardiovascular health. As part of a well-based diet that is low in saturated fat and cholesterol, folic acid, vitamin B6, and vitamin B12 may reduce the risk of vascular disease. FDA evaluated the above claim and found that while it is known that diets low in saturated fat and cholesterol reduce the risk of heart disease and other vascular diseases, the evidence in support of the above claim in inconclusive. Two VCapsules Contain pyridoxal 5’ phosphate (activated B6) 75 mg. folic acid 800 mcg. methylcobalamin (activated B12) 400 mcg. trimethylglycine (anhydrous betaine) 1,000 mg. vitamin C (as ascorbyl palmitate) 10 mg. (hypo-allergenic plant fiber added to complete capsule volume requirement) Dosage: 2 vegetarian capsules per day, in divided doses, with meals. Refrigerate after opening.